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Prognostic significance of being overweight and obese at diagnosis in children with acute lymphoblastic leukemia

Aldhafiri, F.K. and McColl, J.H. and Reilly, J.J. (2014) Prognostic significance of being overweight and obese at diagnosis in children with acute lymphoblastic leukemia. Journal of Pediatric Hematology/Oncology, 36 (3). pp. 234-236. ISSN 1077-4114

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Abstract

This study tested the hypothesis that being overweight/obese at diagnosis of childhood ALL was related to risk of relapse. In a national cohort of 1033 patients from the UK, there was no evidence that weight status at diagnosis was related significantly to risk of relapse: log-rank test (P=0.90) with overweight and obesity as the exposure (n=917); individual (P=0.42) and stepwise (P=0.96) proportional hazards models, with BMI Z score as the exposure. The study does not support the hypothesis that being overweight/obese at diagnosis impairs prognosis in childhood ALL in the UK.