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Open Access research which pushes advances in bionanotechnology

Strathprints makes available scholarly Open Access content by researchers in the Strathclyde Institute of Pharmacy & Biomedical Sciences (SIPBS) , based within the Faculty of Science.

SIPBS is a major research centre in Scotland focusing on 'new medicines', 'better medicines' and 'better use of medicines'. This includes the exploration of nanoparticles and nanomedicines within the wider research agenda of bionanotechnology, in which the tools of nanotechnology are applied to solve biological problems. At SIPBS multidisciplinary approaches are also pursued to improve bioscience understanding of novel therapeutic targets with the aim of developing therapeutic interventions and the investigation, development and manufacture of drug substances and products.

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A re-configurable bipolar and monopolar transmission-line based pulse generator

Beveridge, Joseph and Macgregor, Scott and Wilson, Mark and Timoshkin, Igor (2007) A re-configurable bipolar and monopolar transmission-line based pulse generator. In: IEEE conference record-abstracts. IEEE, Red Hook, NY, p. 792. ISBN 9781424409150

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Transmission-line based generators are used in a wide range of pulsed power applications where short duration, high voltage pulses are required. These generators can be designed to produce pulses with a risetime in the range of nanoseconds to tens of nanoseconds, and magnitudes of up to several hundred kilovolts. One of the more recent uses of HV pulse generation has been in the field of pulsed electric field (PEF) inactivation of microorganisms. Here, electric fields of the order of 30 kV/cm are applied across liquids for a few microseconds in order to achieve microbial inactivation. It has been reported that there are significant performance differences between applying PEF with monopolar and bipolar pulse profiles. The monopolar pulse has single polaritv, either positive or negative, whilst the bipolar pulse is a dual polarity pulse, where the polarity changes half way through the pulse duration. In order to investigate the reported pulse profile effects, a re-configurable pulse generator was designed and developed that produces both monopolar and bipolar pulse. Details of the pulse generator design and operating performance will be discussed along with some information regarding it suitability for PEF inactivation applications.