Modifying alkylzinc reactivity with 2,2 '-dipyridylamide : activation of tBu-Zn bonds for para-alkylation of benzophenone

Armstrong, David R. and Garden, Jennifer A. and Kennedy, Alan R. and Mulvey, Robert and Robertson, Stuart D. (2013) Modifying alkylzinc reactivity with 2,2 '-dipyridylamide : activation of tBu-Zn bonds for para-alkylation of benzophenone. Angewandte Chemie International Edition, 52 (28). pp. 7190-7193. ISSN 1433-7851 (https://doi.org/10.1002/anie.201302426)

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Abstract

Undercover agent: Masquerading as a simple donor-acceptor complex (1), sodium amide substoichiometrically activates tBuZn for the challenging 1,6-addition of a tert-butyl group to benzophenone. In contrast, the nonactivated tBuZn is ineffectual.

ORCID iDs

Armstrong, David R., Garden, Jennifer A., Kennedy, Alan R., Mulvey, Robert ORCID logoORCID: https://orcid.org/0000-0002-1015-2564 and Robertson, Stuart D. ORCID logoORCID: https://orcid.org/0000-0002-9330-8770;
  • Item type:Article
    ID code:44630
    Dates:
    Date
    Event
    8 July 2013
    Published
    5 June 2013
    Published Online
    Keywords:zinc, reagents, ligands, alkylation, metalation, alkali metal, crystal-structure, dipyridylamine, chloride, 2,2-dipyridylamine, sodium TMP-zincate, chemistry, homogeneous catalysis, amides, complexes, Chemistry, Chemistry(all), Biochemistry
    Subjects:Science > Chemistry
    Department:Faculty of Science > Pure and Applied Chemistry
    Depositing user: Pure Administrator
    Date deposited:28 Aug 2013 13:39
    Last modified:07 May 2022 00:12
    Related URLs:
    URI:https://strathprints.strath.ac.uk/id/eprint/44630
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