Modifying alkylzinc reactivity with 2,2 '-dipyridylamide : activation of tBu-Zn bonds for para-alkylation of benzophenone

Armstrong, David R. and Garden, Jennifer A. and Kennedy, Alan R. and Mulvey, Robert and Robertson, Stuart D. (2013) Modifying alkylzinc reactivity with 2,2 '-dipyridylamide : activation of tBu-Zn bonds for para-alkylation of benzophenone. Angewandte Chemie International Edition, 52 (28). pp. 7190-7193. ISSN 1433-7851

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    Abstract

    Undercover agent: Masquerading as a simple donor-acceptor complex (1), sodium amide substoichiometrically activates tBuZn for the challenging 1,6-addition of a tert-butyl group to benzophenone. In contrast, the nonactivated tBuZn is ineffectual.