Modifying alkylzinc reactivity with 2,2 '-dipyridylamide : activation of tBu-Zn bonds for para-alkylation of benzophenone

Armstrong, David R. and Garden, Jennifer A. and Kennedy, Alan and Mulvey, Robert and Robertson, Stuart D. (2013) Modifying alkylzinc reactivity with 2,2 '-dipyridylamide : activation of tBu-Zn bonds for para-alkylation of benzophenone. Angewandte Chemie International Edition, 52 (28). pp. 7190-7193. ISSN 1521-3773 (https://doi.org/10.1002/anie.201302426)

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Abstract

Undercover agent: Masquerading as a simple donor-acceptor complex (1), sodium amide substoichiometrically activates tBuZn for the challenging 1,6-addition of a tert-butyl group to benzophenone. In contrast, the nonactivated tBuZn is ineffectual.

ORCID iDs

Armstrong, David R., Garden, Jennifer A., Kennedy, Alan ORCID logoORCID: https://orcid.org/0000-0003-3652-6015, Mulvey, Robert ORCID logoORCID: https://orcid.org/0000-0002-1015-2564 and Robertson, Stuart D. ORCID logoORCID: https://orcid.org/0000-0002-9330-8770;
CORE (COnnecting REpositories)