Addressable and unidirectional energy transfer along a DNA three-way junction programmed by pyrrole-imidazole polyamides

Tools

Su, Wu and Bagshaw, Clive R. and Burley, Glenn A. (2013) Addressable and unidirectional energy transfer along a DNA three-way junction programmed by pyrrole-imidazole polyamides. Scientific Reports, 3. 1883. ISSN 2045-2322 (https://doi.org/10.1038/srep01883)

[thumbnail of SuBagshawBurley_ScientificReports2013]
Preview
 PDF. Filename: Adressable_and_unidirectional_energy.pdf
Final Published Version
License: Creative Commons Attribution 4.0 logo
Download (1MB)| Preview

Abstract

We describe a photonic waveguide where FRET is routed uni-directionally along a double-stranded DNA track. The efficiency of FRET is modulated by the supramolecular control of fluorophores along double-stranded DNA using fluorophore-tethered Pyrrole-Imidazole polyamides (PAs). We show that uni-directional FRET is enhanced by the complete assembly of each of the constituent parts, resulting in the selective routing of light along simple DNA duplexes as well as a three-way junction (3WJ).

CORE (COnnecting REpositories)