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Open Access research which pushes advances in bionanotechnology

Strathprints makes available scholarly Open Access content by researchers in the Strathclyde Institute of Pharmacy & Biomedical Sciences (SIPBS) , based within the Faculty of Science.

SIPBS is a major research centre in Scotland focusing on 'new medicines', 'better medicines' and 'better use of medicines'. This includes the exploration of nanoparticles and nanomedicines within the wider research agenda of bionanotechnology, in which the tools of nanotechnology are applied to solve biological problems. At SIPBS multidisciplinary approaches are also pursued to improve bioscience understanding of novel therapeutic targets with the aim of developing therapeutic interventions and the investigation, development and manufacture of drug substances and products.

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Modeling focused beam reflectance measurement and its application to sizing of particles of variable shape

Vaccaro, Andrea and Sefcik, Jan and Morbidelli, Massimo (2007) Modeling focused beam reflectance measurement and its application to sizing of particles of variable shape. Particle and Particle Systems Characterization, 23 (5). pp. 360-373. ISSN 0934-0866

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Abstract

A model for particle detection in focused beam reflectance measurement is presented in the general case of particles of any convex shape. Shape dependent convolution relationships between measured chord length distribution (CLD), particle size distribution (PSD) and particle mass distribution (PMD) are derived and an explicit formula for the weighting characteristic length is given in terms of particle shape. Based on the derived convolution relationships, equations relating moments of the CLD, PSD and PMD are obtained. Issues related to the definition of particle size of non spherical objects and its connection to the particle sizing technique are discussed. Based on the moment relationships, particle size is defined for focused beam reflectance measurement measurements in terms of a CLD equivalent sphere. CLD and characteristic length for a thin cylinder are obtained analytically and used as simple model in order to illustrate issues in sizing particles of variable shape, General conclusions regarding the role of the weighting characteristic length on the behavior of the measured CLD are drawn.