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Open Access research which pushes advances in bionanotechnology

Strathprints makes available scholarly Open Access content by researchers in the Strathclyde Institute of Pharmacy & Biomedical Sciences (SIPBS) , based within the Faculty of Science.

SIPBS is a major research centre in Scotland focusing on 'new medicines', 'better medicines' and 'better use of medicines'. This includes the exploration of nanoparticles and nanomedicines within the wider research agenda of bionanotechnology, in which the tools of nanotechnology are applied to solve biological problems. At SIPBS multidisciplinary approaches are also pursued to improve bioscience understanding of novel therapeutic targets with the aim of developing therapeutic interventions and the investigation, development and manufacture of drug substances and products.

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Chemical functionalisation and geometrical modification of cellulose fibrous networks for tissue engineering

Eichhorn, Stephen J. and Gough, Julie E. and Ulijn, Rein V. and Sampson, William W. and Kalaskar, Deepak and Cai, Shijie (2006) Chemical functionalisation and geometrical modification of cellulose fibrous networks for tissue engineering. In: 231st ACS National Meeting, 2006-03-26 - 2006-03-30.

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Abstract

The use of chemically modified cellulose fibrous networks for the binding and proliferation of fibroblast cells is reported. Specifically the use of glycine and fmoc-proteced glycine groups to promote cell adhesion to the fibre surfaces and to enable proliferation in the porous structures of the networks respectively is presented. The geometry, including control of the pore size and porosity, is also presented as a means to control the proliferation and cell morphology. The cell morphologies are reported using Scanning Electron Microscopy and an MTT assay is presented to show the proliferation rates of the cells. Results from Confocal Laser Scanning Microscopy with specific collagen and cell-nucleus staining is also reported to highlight the efficacy of chemical treatments