Controlling cell morphology on amino acid-modified cellulose

Kalaskar, Deepak M. and Gough, Julie E. and Ulijn, Rein V. and Sampson, William W. and Scurr, David J. and Rutten, Frank J. and Alexander, Morgan R. and Merry, Catherine L. R. and Eichhorn, Stephen J. (2008) Controlling cell morphology on amino acid-modified cellulose. Soft Matter, 4 (5). pp. 1059-1065. ISSN 1744-6848

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Abstract

This study shows that it is possible to affect the morphology and spreading of fibroblast cells on amino acid-modified cellulose-based fibrous networks. Hydrophilic (Gly, Ser), aliphatic (Ala, Val, Leu, Ile) and aromatic amino acids (Phe, Tyr, Trp), coupled to the cellulose via esterification, give rise to different cell morphologies. Modified cellulosic substrates are analysed using time of flight secondary ion mass spectrometry (TOF-SIMS), demonstrating that amino acids are coupled and uniformly distributed over the surface of the samples. Remarkably, it is shown that it is the aromatic amino acids, and in particular Trp, that give rise to significantly enhanced cell spreading. This enhanced effect is shown to be linked to an increase in the adsorption of fibronectin in the presence of aromatic bound amino acids.

Author(s):Kalaskar, Deepak M., Gough, Julie E., Ulijn, Rein V., Sampson, William W., Scurr, David J., Rutten, Frank J., Alexander, Morgan R., Merry, Catherine L. R. and Eichhorn, Stephen J.
Item type:Article
ID code:43957
Keywords:control, cell morphology, amino acid-modified cellulose, Chemistry, Chemistry(all), Condensed Matter Physics
Subjects:Science > Chemistry
Department:Faculty of Science > Pure and Applied Chemistry
Depositing user: Pure Administrator
Date deposited:30 May 2013 12:13
Last modified:14 Jun 2019 13:01
URI:https://strathprints.strath.ac.uk/id/eprint/43957
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