Controlling cell morphology on amino acid-modified cellulose
Kalaskar, Deepak M. and Gough, Julie E. and Ulijn, Rein V. and Sampson, William W. and Scurr, David J. and Rutten, Frank J. and Alexander, Morgan R. and Merry, Catherine L. R. and Eichhorn, Stephen J. (2008) Controlling cell morphology on amino acid-modified cellulose. Soft Matter, 4 (5). pp. 1059-1065. ISSN 1744-6848
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This study shows that it is possible to affect the morphology and spreading of fibroblast cells on amino acid-modified cellulose-based fibrous networks. Hydrophilic (Gly, Ser), aliphatic (Ala, Val, Leu, Ile) and aromatic amino acids (Phe, Tyr, Trp), coupled to the cellulose via esterification, give rise to different cell morphologies. Modified cellulosic substrates are analysed using time of flight secondary ion mass spectrometry (TOF-SIMS), demonstrating that amino acids are coupled and uniformly distributed over the surface of the samples. Remarkably, it is shown that it is the aromatic amino acids, and in particular Trp, that give rise to significantly enhanced cell spreading. This enhanced effect is shown to be linked to an increase in the adsorption of fibronectin in the presence of aromatic bound amino acids.
Author(s): | Kalaskar, Deepak M., Gough, Julie E., Ulijn, Rein V. ![]() | Item type: | Article |
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ID code: | 43957 |
Keywords: | control, cell morphology, amino acid-modified cellulose, Chemistry, Chemistry(all), Condensed Matter Physics |
Subjects: | Science > Chemistry |
Department: | Faculty of Science > Pure and Applied Chemistry |
Depositing user: | Pure Administrator |
Date deposited: | 30 May 2013 12:13 |
Last modified: | 25 Oct 2019 04:13 |
URI: | https://strathprints.strath.ac.uk/id/eprint/43957 |
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