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Improved biotransformations on charged PEGA supports

Basso, A and De Martin, L and Gardossi, L and Margetts, G and Brazendale, I and Bosma, A Y and Ulijn, R V and Flitsch, S L (2003) Improved biotransformations on charged PEGA supports. Chemical Communications (11). pp. 1296-1297. ISSN 1359-7345

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Abstract

PEGA supports functionalised with permanent charges show superior swelling properties in aqueous media when compared to neutral PEGA; a novel positively charged PEGA resin significantly improves penicillin G amidase (PGA) catalysed biotransformation on solid support, by favouring accessibility of the negatively charged enzyme.