A systematic study on the self-assembly behaviour of multi component fmoc-amino acid-poly(oxazoline) systems

Caponi, Pier-Francesco and Ulijn, Rein V. (2012) A systematic study on the self-assembly behaviour of multi component fmoc-amino acid-poly(oxazoline) systems. Polymers, 4 (3). pp. 1399-1415. ISSN 2073-4360

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    Abstract

    We report a systematic study of a modular approach to create multi-component supramolecular nanostructures that can be tailored to be both enzyme and temperature responsive. Using a straightforward synthetic approach we functionalised a thermal responsive polymer, poly(2-isopropyl-2-oxazoline), with fluorenylmethoxycarbonyl-amino acids that drive the self-assembly. Depending on the properties of appended amino acids, these polymers undergo substantial morphological changes in response to the catalytic action of alkaline phosphatase.