Mast cells and vascular diseases

Kennedy, Simon and Wu, Junxi and Wadsworth, Roger and Lawrence, Catherine and Maffia, Pasquale (2013) Mast cells and vascular diseases. Pharmacology and Therapeutics, 138 (1). pp. 53-65. ISSN 0163-7258

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Abstract

Mast cells are increasingly being recognized as effector cells in many cardiovascular conditions. Many mast-cell-derived products such as tryptase and chymase can, through their enzymic action, have detrimental effects on blood vessel structure while mast cell-derived mediators such as cytokines and chemokines can perpetuate vascular inflammation. Mice lacking mast cells have been developed and these are providing an insight into how mast cells are involved in cardiovascular diseases and, as knowledge increase, mast cells may become a viable therapeutic target to slow progression of cardiovascular disease