Global phylogeny of Shigella sonnei from limited single nucleotide polymorphisms and development of a rapid and cost-effective SNP-typing scheme for strain identification by high resolution melting : rapid SNP-typing S. sonnei

Sangal, Vartul and Holt, K.E. and Yuan, J and Brown, D.J. and Filliol-Toutain, I. and Weill, François-Xavier and Kim, D.W. and da Silveira, W.D. and Pickard, D. and Thomson, N.R. and Parkhill, J. and Yu, Jun (2013) Global phylogeny of Shigella sonnei from limited single nucleotide polymorphisms and development of a rapid and cost-effective SNP-typing scheme for strain identification by high resolution melting : rapid SNP-typing S. sonnei. Journal of Clinical Microbiology. ISSN 0095-1137

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Abstract

The current Shigella sonnei pandemic involves geographically associated, multidrug resistant clones. This study has demonstrated that S. sonnei phylogeny can be accurately defined with limited SNPs. By typing 6 informative SNPs using high-resolution melting (HRM) assay major S. sonnei lineages/sublineages can be identified as defined from whole-genome variation.