Helminth-derived immunomodulators : can understanding the worm produce the pill?

Harnett, W. and Harnett, M.M. (2010) Helminth-derived immunomodulators : can understanding the worm produce the pill? Nature Reviews Immunology, 10 (4). pp. 278-284. ISSN 1474-1733

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Abstract

Helminths may protect humans against allergic and autoimmune diseases and, indeed, defined helminth-derived products have recently been shown to prevent the development of such inflammatory diseases in mouse models. Here, we propose that helminth-derived products not only have therapeutic potential but can also be used as unique tools for defining key molecular events in the induction of an anti-inflammatory response and, therefore, for defining new therapeutic targets.