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Open Access research with a European policy impact...

The Strathprints institutional repository is a digital archive of University of Strathclyde's Open Access research outputs. Strathprints provides access to thousands of Open Access research papers by Strathclyde researchers, including by researchers from the European Policies Research Centre (EPRC).

EPRC is a leading institute in Europe for comparative research on public policy, with a particular focus on regional development policies. Spanning 30 European countries, EPRC research programmes have a strong emphasis on applied research and knowledge exchange, including the provision of policy advice to EU institutions and national and sub-national government authorities throughout Europe.

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Creating permanent 3D arrangements of isolated cells using holographic optical tweezers

Jordan, P. and Leach, J. and Padgett, M.J. and Blackburn, P. and Isaacs, N. and Goksor, M. and Hanstorp, D. and Wright, A.J. and Girkin, J.M. and Cooper, J. (2005) Creating permanent 3D arrangements of isolated cells using holographic optical tweezers. Lab on a Chip, 5 (11). pp. 1224-1228. ISSN 1473-0197

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Abstract

Reports the creation of permanent 3D configurations of cells, at predefined positions, within a gelatin matrix. The technique used holographic optical tweezers to manipulate individual E. coli within a solution comprising monomer precursors. The matrix was then set and after the laser beam was removed, we were able to demonstrate that the structures remained intact for many days. We were also able to demonstrate that, in the presence of appropriate nutrients, the E. coli survived within the gelatin matrix for several days. The technique could have a number of potential future applications, including the arrangement of a variety of different cell types in complex architectures, as motifs for promoting tissue differentiation and growth within the field of cell engineering.