Picture of boy being examining by doctor at a tuberculosis sanatorium

Understanding our future through Open Access research about our past...

Strathprints makes available scholarly Open Access content by researchers in the Centre for the Social History of Health & Healthcare (CSHHH), based within the School of Humanities, and considered Scotland's leading centre for the history of health and medicine.

Research at CSHHH explores the modern world since 1800 in locations as diverse as the UK, Asia, Africa, North America, and Europe. Areas of specialism include contraception and sexuality; family health and medical services; occupational health and medicine; disability; the history of psychiatry; conflict and warfare; and, drugs, pharmaceuticals and intoxicants.

Explore the Open Access research of the Centre for the Social History of Health and Healthcare. Or explore all of Strathclyde's Open Access research...

Image: Heart of England NHS Foundation Trust. Wellcome Collection - CC-BY.

Sex differences in trabecular bone microarchitecture are not detected in pre and early pubertal children using magnetic resonance imaging

Modlesky, C. M. and Bajaj, D. and Kirby, J. T. and Mulrooney, B. M. and Rowe, D. A. and Miller, F. (2011) Sex differences in trabecular bone microarchitecture are not detected in pre and early pubertal children using magnetic resonance imaging. BONE, 49 (5). pp. 1067-1072. ISSN 8756-3282

Full text not available in this repository. Request a copy from the Strathclyde author

Abstract

Sex differences in trabecular bone microarchitecture have been reported in adults and adolescents, but studies in children are lacking. The primary aim of this study was to determine if there are sex differences in magnetic resonance imaging (MRI)-based measures of trabecular bone microarchitecture at the distal femur of children. Pre and early pubertal boys (n = 23) and girls (n = 20) between the 5th and 95th percentiles for height, body mass and BMI were studied. Apparent trabecular bone volume to total volume (appBV/TV), trabecular number (appTb.N), trabecular thickness (appTb.Th), trabecular separation (appTb.Sp) and a composite measure of trabecular bone microarchitecture (TBMcom) were assessed at the lateral aspect of the distal femur using MRI. Areal bone mineral density (aBMD), bone mineral content (BMC) and bone area were assessed at the distal femur using dual-energy X-ray absorptiometry (DXA). Tanner staging was used to assess pubertal development. Physical activity was assessed using an accelerometry-based activity monitor. Calcium intake was assessed using diet records. There were no sex differences in age, height, femur length, body mass, physical activity or calcium intake (all P > 0.05). There were no sex differences in any MRI-based measure of trabecular bone microarchitecture. Consistent with the MRI-based measures, there were no differences in aBMD, BMC or bone area from DXA at the distal femur (P > 0.05). appBV/TV, appTb.N, appTb.Th, appTb.Sp and TBMcom were also moderately to strongly related to aBMD (r = 0.73, 0.63, 0.51, − 0.74 and 0.61, respectively, p < 0.001) and BMC (r = 0.84, 0.63, 0.66, − 0.80 and 0.77, respectively, P < 0.001). The findings suggest that there are no differences in measures of trabecular bone microarchitecture at the distal femur of pre and early pubertal boys and girls who are similar in size, physical activity and calcium intake. Future studies with larger sample sizes that cover all pubertal stages are needed to determine if sex differences in trabecular bone microarchitecture emerge at the distal femur and other weight bearing bone sites.