An RNA splicing enhancer that does not act by looping

Lewis, Helen and Perrett, Andrew and Burley, Glenn and Eperon, Ian (2012) An RNA splicing enhancer that does not act by looping. Angewandte Chemie International Edition, 51 (39). 9800–9803. ISSN 1521-3773 (https://doi.org/10.1002/anie.201202932)

Abstract

Do the proteins bound to an enhancer site on pre-mRNA interact directly with the splice site by diffusion (looping), as is generally accepted, or does the intervening RNA play a role (see scheme)? By inserting a PEG linker between an enhancer sequence and alternative splice sites, the interaction of these two elements can be studied. Intervening RNA was essential for the enhancer activity, which rules out the looping model.

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• Item metadata

  Item type:	Article
  ID code:	41207
  Dates:	Date Event 24 September 2012 Published 31 August 2012 Published Online
  Subjects:	Science > Chemistry
  Department:	Faculty of Science > Pure and Applied Chemistry Technology and Innovation Centre > Bionanotechnology
  Depositing user:	Pure Administrator
  Date deposited:	20 Sep 2012 13:16
  Last modified:	11 Nov 2024 10:13
  Related URLs:	Journal or Publication
  URI:	https://strathprints.strath.ac.uk/id/eprint/41207