Poly(lactide-co-glycolide) nanoparticles for peroral delivery of bioactives

Grama, C. N. and Ankola, D. D. and Kumar, M. N. V. R. (2011) Poly(lactide-co-glycolide) nanoparticles for peroral delivery of bioactives. Current Opinion in Colloid and Interface Science, 16 (3). pp. 238-245. ISSN 1359-0294

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Abstract

The benefits of increasing surface area to volume ratio have long been realized by the pharmaceutical industry for addressing the solubility limited oral bioavailability. In the recent past various excipients that include but not limited to polymers and lipids are used to engineer nanostructures that possess one or more of the following properties, improve oral bioavailability, improve therapeutic efficacy, sustain the release of the encapsulated bioactive, minimize toxicity, have the ability to target the pathological site of interest and also perform dual role of diagnosis and delivery of bioactives simultaneously. In this review, we attempt to discuss the use of poly(lactide-co-glycolide) (PLGA) nanoparticles in addressing the solubility/permeability limited bioavailability problems of various bioactives that include drugs as well as antioxidants.

Author(s):Grama, C. N., Ankola, D. D. and Kumar, M. N. V. R.
Item type:Article
ID code:40694
Keywords:Antioxidants, oral delivery, biodegradable nanoparticles, plga nanoparticles, encapsulated antioxidant nanoparticles, gastrointes, nanoparticles, polymeric nanoparticles, bioavailability, plga, behavior in-vitro, ellagic acid, biodegradable, drug-delivery, poly(lactide-co-glycolide) nanoparticles, peroral delivery, bioactives, Pharmacy and materia medica, Polymers and Plastics, Colloid and Surface Chemistry, Physical and Theoretical Chemistry, Surfaces and Interfaces
Subjects:Medicine > Pharmacy and materia medica
Department:Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Technology and Innovation Centre > Bionanotechnology
Depositing user: Pure Administrator
Date deposited:02 Aug 2012 13:56
Last modified:03 Jan 2020 08:48
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URI:https://strathprints.strath.ac.uk/id/eprint/40694
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