Phosphatase/temperature responsive poly(2-isopropyl-2-oxazoline)

Caponi, P. F. and Qiu, X. P. and Vilela, F. and Winnik, F. M. and Ulijn, R. V. (2011) Phosphatase/temperature responsive poly(2-isopropyl-2-oxazoline). Polymer Chemistry, 2. pp. 306-308. ISSN 1759-9954

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Abstract

We demonstrate a strategy for producing polymer bioconjugates which display both enzymatic and thermal responsiveness. This is achieved by combining the thermo-responsive properties of poly(2-isopropyl-2-oxazoline) (PiPrOx) with the self-assembly properties of fluorenylmethoxycarbonyl-tyrosine (Fmoc-Y), controlled by a phosphatase triggered mechanism.