Picture of boy being examining by doctor at a tuberculosis sanatorium

Understanding our future through Open Access research about our past...

Strathprints makes available scholarly Open Access content by researchers in the Centre for the Social History of Health & Healthcare (CSHHH), based within the School of Humanities, and considered Scotland's leading centre for the history of health and medicine.

Research at CSHHH explores the modern world since 1800 in locations as diverse as the UK, Asia, Africa, North America, and Europe. Areas of specialism include contraception and sexuality; family health and medical services; occupational health and medicine; disability; the history of psychiatry; conflict and warfare; and, drugs, pharmaceuticals and intoxicants.

Explore the Open Access research of the Centre for the Social History of Health and Healthcare. Or explore all of Strathclyde's Open Access research...

Image: Heart of England NHS Foundation Trust. Wellcome Collection - CC-BY.

Natural and synthetic polyesters for musculoskeletal tissue repair: experimental in vitro and in vivo evaluations

Giavaresi, G. and Tschon, M. and Daly, J.H. and Liggat, J.J. and Fini, M. and Torricelli, P. and Giardino, R. (2004) Natural and synthetic polyesters for musculoskeletal tissue repair: experimental in vitro and in vivo evaluations. International Journal of Artificial Organs, 27 (9). pp. 796-805. ISSN 0391-3988

Full text not available in this repository. Request a copy from the Strathclyde author

Abstract

Two natural Biopol(TM) polyesters, containing 8% (D400G) and 12% (D600G) of hydroxyvalerate component, and a synthetic polyester based on 1,4 cyclohexanediol [Poly(cyclohexyl-sebacate) - PCS] were studied to investigate their in vitro and in vivo behavior for application in musculoskeletal tissue repair. The polyesters were placed in direct contact with L929 fibroblasts and cell proliferation (WST-1), cytotoxic effect (LDH), synthetic activity (total proteins) and cytokine production (IL-1beta, IL-6, TNFalpha) were assessed after an incubation period of 72 hours and 7 days. Then, 12 Sprague-Dawley rats underwent dorsal subcutaneous implants of tested polyesters under general anesthesia. After 1 and 4 weeks from surgery, the animals were pharmacologically euthanized and the implants retrieved with surrounding tissue for histologic and histomorphometric investigations. In vitro results showed that D600G behaved a little worse in comparison to other tested polyesters in terms of cell proliferation and TNFalpha at 7 days. PCS presented the lowest total protein value at 7 days. In vivo results indicated that PCS implants produced a higher (p < 0.01) extent of inflammatoty tissue in comparison to D600G at 1 week and to D40OG at 4 weeks, and the lowest vascular densities at both experimental times. D40OG seems to be the most suitable material for biomedical application when tested in fibroblast cultures and in the subcutaneous tissue of rats.