New anthracene derivatives – structure elucidation and antimicrobial activity

Debbab, Abdessamad and Aly, Amal H. and Edrada-Ebel, Ruangelie and Wray, Victor and Pretsch, Alexander and Pescitelli, Gennaro and Kurtan, Tibor and Proksch, Peter (2012) New anthracene derivatives – structure elucidation and antimicrobial activity. European Journal of Organic Chemistry, 2012. pp. 1351-1359. ISSN 1434-193X

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Abstract

Three new anthracene derivatives, which include tetrahydroanthraquinone 1 and two tetrahydroanthraquinone heterodimers 2 and 3, were isolated from Stemphylium globuliferum, together with four known metabolites 4–7. Detailed analysis of the spectroscopic data allowed the unambiguous determination of the structures of 1 and 2 and a revision of the structure of alterporriol C and its atropisomer. Furthermore, alterporriol G, previously obtained as part of a mixture, was isolated in its pure form for the first time and its structure was also revised. The absolute configurations of 1, 2 and 3 were assigned by calculation of their CD spectra, which also allowed the configurational assignment of altersolanol A and the determination of the axial chirality of alterporriols D and E. All isolated compounds were analysed for their antimicrobial and cytotoxic activities. Compounds 1 and 5 inhibited the growth of most pathogenic microorganisms tested, whereas 2, 6 and 7 showed selective inhibition of bacteria but were inactive against fungi.

Author(s):Debbab, Abdessamad, Aly, Amal H., Edrada-Ebel, Ruangelie, Wray, Victor, Pretsch, Alexander, Pescitelli, Gennaro, Kurtan, Tibor and Proksch, Peter
Item type:Article
ID code:38661
Keywords:natural products, antibiotics, structure elucidation, circular dichroism, quinone, Chemistry, Organic Chemistry, Physical and Theoretical Chemistry
Subjects:Science > Chemistry
Department:Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Depositing user: Pure Administrator
Date deposited:23 Mar 2012 13:53
Last modified:23 Aug 2019 09:09
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URI:https://strathprints.strath.ac.uk/id/eprint/38661
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