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Synthesis, full chemical characterisation and development of validated methods for the quantification of the components found in the evolved “legal high” NRG-2

Khreit, Osama I. G. and Irving, Craig and Schmidt, Elke and Parkinson, John A. and Daeid, Niamh Nic and Sutcliffe, Oliver B. (2012) Synthesis, full chemical characterisation and development of validated methods for the quantification of the components found in the evolved “legal high” NRG-2. Journal of Pharmaceutical and Biomedical Analysis, 61. pp. 122-135. ISSN 0731-7085

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Abstract

The recent global increase in the abuse of 4-methylmethcathinone (mephedrone) and related compounds has developed a requirement for full chemical characterisation of these products. This work presents full synthetic and chemical characterisation data for the hydrobromide salts of two mephedrone derivatives: 4-methyl-N-ethylcathinone (4-MEC) and 4-methyl-N-benzylcathinone (4-MBC) which have been identified in samples of the “legal high” NRG-2. The first fully validated chromatographic methods for the detection and quantitative analysis of these substances both in their pure form and in the presence of a number of common adulterants used in illicit drug manufacture is also reported.