Self-assembly of cetyl linear polyethylenimine to give micelles, vesicles, and dense nanoparticles

Gray, A. (2004) Self-assembly of cetyl linear polyethylenimine to give micelles, vesicles, and dense nanoparticles. Macromolecules, 37 (24). pp. 9114-9122. ISSN 0024-9297

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Abstract

The involvement of macromolecules in the formation of biological and other membranes has important implications for structural biology and nanoengineering. Using cetyl polyethylenimines of varying molecular weight and hydrophobicity, it was found that polymer hydrophobicity (mol % cetylation) controlled the nature of the self-assembly, giving micellar (cetyl groups < 23 mol %), vesicular (cetyl groups = 23−42 mol % or cetyl groups = 3−42 mol % with cholesterol), and dense nanoparticle (cetyl groups ≥ 49 mol %) aggregates. Thick (up to 15 nm) membranes due to the polyelectrolyte coating with the amphiphile were observed with low levels of cetylation only, and both dn/dc (indirectly) and vesicle/nanoparticle size (directly) varied linearly with mol % cetylation (r = 0.96−0.99).

  • Item type:Article
    ID code:38026
    Dates:
    Date
    Event
    2004
    Published
    Keywords:cetyl linear polyethylenimine , micelles, vesicles, nanoparticles, Pharmacy and materia medica, Materials Chemistry, Organic Chemistry, Polymers and Plastics, Inorganic Chemistry
    Subjects:Medicine > Pharmacy and materia medica
    Department:Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
    Depositing user: Pure Administrator
    Date deposited:29 Feb 2012 16:08
    Last modified:06 Aug 2021 02:42
    URI:https://strathprints.strath.ac.uk/id/eprint/38026
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