Self-assembly of cetyl linear polyethylenimine to give micelles, vesicles, and dense nanoparticles

Gray, A. (2004) Self-assembly of cetyl linear polyethylenimine to give micelles, vesicles, and dense nanoparticles. Macromolecules, 37 (24). pp. 9114-9122. ISSN 0024-9297

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Abstract

The involvement of macromolecules in the formation of biological and other membranes has important implications for structural biology and nanoengineering. Using cetyl polyethylenimines of varying molecular weight and hydrophobicity, it was found that polymer hydrophobicity (mol % cetylation) controlled the nature of the self-assembly, giving micellar (cetyl groups < 23 mol %), vesicular (cetyl groups = 23−42 mol % or cetyl groups = 3−42 mol % with cholesterol), and dense nanoparticle (cetyl groups ≥ 49 mol %) aggregates. Thick (up to 15 nm) membranes due to the polyelectrolyte coating with the amphiphile were observed with low levels of cetylation only, and both dn/dc (indirectly) and vesicle/nanoparticle size (directly) varied linearly with mol % cetylation (r = 0.96−0.99).

Author(s):Gray, A.
Item type:Article
ID code:38026
Keywords:cetyl linear polyethylenimine , micelles, vesicles, nanoparticles, Pharmacy and materia medica, Materials Chemistry, Organic Chemistry, Polymers and Plastics, Inorganic Chemistry
Subjects:Medicine > Pharmacy and materia medica
Department:Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Depositing user: Pure Administrator
Date deposited:29 Feb 2012 16:08
Last modified:03 Jan 2019 11:56
URI:https://strathprints.strath.ac.uk/id/eprint/38026
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