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Open Access research which pushes advances in bionanotechnology

Strathprints makes available scholarly Open Access content by researchers in the Strathclyde Institute of Pharmacy & Biomedical Sciences (SIPBS) , based within the Faculty of Science.

SIPBS is a major research centre in Scotland focusing on 'new medicines', 'better medicines' and 'better use of medicines'. This includes the exploration of nanoparticles and nanomedicines within the wider research agenda of bionanotechnology, in which the tools of nanotechnology are applied to solve biological problems. At SIPBS multidisciplinary approaches are also pursued to improve bioscience understanding of novel therapeutic targets with the aim of developing therapeutic interventions and the investigation, development and manufacture of drug substances and products.

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Evidence for extreme activation of carbon-hydrogen bonds in [(PhCH2)2NNa]n : resultant carbon-hydrogen bond cleavage to give {[PhC(H)NC(H)Ph]Na.cntdot.PMDETA}n

Andrews, Philip C. and Armstrong, David R. and Mulvey, Robert and Reed, David (1988) Evidence for extreme activation of carbon-hydrogen bonds in [(PhCH2)2NNa]n : resultant carbon-hydrogen bond cleavage to give {[PhC(H)NC(H)Ph]Na.cntdot.PMDETA}n. Journal of the American Chemical Society, 110 (15). pp. 5235-5236. ISSN 0002-7863

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Abstract

In organolithium chemistry evidence is accumulating that lithium atoms situated in abnormally low coordination environments then proceed to interact with nearby CH units of the ligands. For example, the crystal structure of [(PhCH,),NLi], revealed a planar (NLi)3 ring whose formally just two-coordinate metal atoms form close contacts with CHpCoCH portions of the benzyl groups.