Metabonomics as a clinical tool of analysis : LC-MS approaches
Alzweiri, Muhammed and Watson, David G. and Parkinson, John A. (2013) Metabonomics as a clinical tool of analysis : LC-MS approaches. Journal of Liquid Chromatography and Related Technologies, 36 (1). pp. 94-115.
Full text not available in this repository.Request a copy from the Strathclyde authorAbstract
Metabolic differences between test and control groups (i.e. metabonomics) are routinely accomplished by using multivariate analysis for data obtained commonly from NMR, GC-MS and LC-MS. Multivariate analysis (e.g. principal component analysis PCA) is commonly used to extract potential metabolites responsible for clinical observations. Metabonomics applied to the clinical field is challenging because the physiological variabilities like gender, age, race…etc might govern the cluster pattern obtained by multivariate analysis instead of the tested differences. This review focuses on the challenges facing the clinical applications of metabonomics and introduces their possible solutions as mentioned in the literature.
| Author(s): | Alzweiri, Muhammed, Watson, David G.  ORCID: https://orcid.org/0000-0003-1094-7604 and Parkinson, John A. ORCID: https://orcid.org/0000-0003-4270-6135 | Item type: | Article |
|---|---|
| ID code: | 36218 |
| Keywords: | principal component analysis, LC-MS, metabolic profiling, metabonomics, multivariate analysis, NMR, Pharmacy and materia medica, Biochemistry, Pharmaceutical Science, Analytical Chemistry, Clinical Biochemistry |
| Subjects: | Medicine > Pharmacy and materia medica |
| Department: | Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences Faculty of Science > Pure and Applied Chemistry |
| Depositing user: | Pure Administrator |
| Date deposited: | 01 Dec 2011 10:34 |
| Last modified: | 03 Jan 2020 08:31 |
| Related URLs: | |
| URI: | https://strathprints.strath.ac.uk/id/eprint/36218 |
| Export data: |
CORE (COnnecting REpositories)
CORE (COnnecting REpositories)