Picture of DNA strand

Pioneering chemical biology & medicinal chemistry through Open Access research...

Strathprints makes available scholarly Open Access content by researchers in the Department of Pure & Applied Chemistry, based within the Faculty of Science.

Research here spans a wide range of topics from analytical chemistry to materials science, and from biological chemistry to theoretical chemistry. The specific work in chemical biology and medicinal chemistry, as an example, encompasses pioneering techniques in synthesis, bioinformatics, nucleic acid chemistry, amino acid chemistry, heterocyclic chemistry, biophysical chemistry and NMR spectroscopy.

Explore the Open Access research of the Department of Pure & Applied Chemistry. Or explore all of Strathclyde's Open Access research...

Strathprints

Metabonomics as a clinical tool of analysis : LC-MS approaches

Alzweiri, Muhammed and Watson, David G. and Parkinson, John A. (2013) Metabonomics as a clinical tool of analysis : LC-MS approaches. Journal of Liquid Chromatography and Related Technologies, 36 (1). pp. 94-115.

Full text not available in this repository. Request a copy from the Strathclyde author

Abstract

Metabolic differences between test and control groups (i.e. metabonomics) are routinely accomplished by using multivariate analysis for data obtained commonly from NMR, GC-MS and LC-MS. Multivariate analysis (e.g. principal component analysis PCA) is commonly used to extract potential metabolites responsible for clinical observations. Metabonomics applied to the clinical field is challenging because the physiological variabilities like gender, age, race…etc might govern the cluster pattern obtained by multivariate analysis instead of the tested differences. This review focuses on the challenges facing the clinical applications of metabonomics and introduces their possible solutions as mentioned in the literature.

Item type: Article
ID code: 36218
Keywords: principal component analysis, LC-MS, metabolic profiling, metabonomics, multivariate analysis, NMR, Pharmacy and materia medica, Biochemistry, Pharmaceutical Science, Analytical Chemistry, Clinical Biochemistry
Subjects: Medicine > Pharmacy and materia medica
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Faculty of Science > Pure and Applied Chemistry
Depositing user: Pure Administrator
Date deposited: 01 Dec 2011 10:34
Last modified: 03 Jan 2019 13:12
Related URLs:
URI: https://strathprints.strath.ac.uk/id/eprint/36218
Export data:
CORE (COnnecting REpositories)