Metabonomics as a clinical tool of analysis : LC-MS approaches

Alzweiri, Muhammed and Watson, David G. and Parkinson, John A. (2013) Metabonomics as a clinical tool of analysis : LC-MS approaches. Journal of Liquid Chromatography and Related Technologies, 36 (1). pp. 94-115.

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Abstract

Metabolic differences between test and control groups (i.e. metabonomics) are routinely accomplished by using multivariate analysis for data obtained commonly from NMR, GC-MS and LC-MS. Multivariate analysis (e.g. principal component analysis PCA) is commonly used to extract potential metabolites responsible for clinical observations. Metabonomics applied to the clinical field is challenging because the physiological variabilities like gender, age, race…etc might govern the cluster pattern obtained by multivariate analysis instead of the tested differences. This review focuses on the challenges facing the clinical applications of metabonomics and introduces their possible solutions as mentioned in the literature.

Creators(s): Alzweiri, Muhammed, Watson, David G. ORCID logoORCID: https://orcid.org/0000-0003-1094-7604 and Parkinson, John A. ORCID logoORCID: https://orcid.org/0000-0003-4270-6135;
Item type:Article
ID code:36218
Keywords:principal component analysis, LC-MS, metabolic profiling, metabonomics, multivariate analysis, NMR, Pharmacy and materia medica, Biochemistry, Pharmaceutical Science, Analytical Chemistry, Clinical Biochemistry
Subjects:Medicine > Pharmacy and materia medica
Department:Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Faculty of Science > Pure and Applied Chemistry
Depositing user: Pure Administrator
Date deposited:01 Dec 2011 10:34
Last modified:03 Sep 2020 03:01
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URI:https://strathprints.strath.ac.uk/id/eprint/36218
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