Novel enrofloxacin imprinted polymer applied to the solid-phase extraction of fluorinated quinolones from urine and tissue samples

Caro, Ester and Marcé, Rosa M. and Cormack, Peter A.G. and Sherrington, David C. and Borrull, Francesc (2006) Novel enrofloxacin imprinted polymer applied to the solid-phase extraction of fluorinated quinolones from urine and tissue samples. Analytica Chimica Acta, 562 (2). pp. 145-151. ISSN 0003-2670 (https://doi.org/10.1016/j.aca.2006.01.080)

Abstract

A new molecularly imprinted polymer, prepared following a non-covalent approach, was synthesised using enrofloxacin as a template molecule. The imprinting effect of the polymer was verified by chromatographic evaluation and, interestingly, this evaluation also revealed that the imprinted polymer showed a high degree of cross-reactivity for ciprofloxacin, the major metabolite of enrofloxacin. The molecularly imprinted polymer was then applied as a selective sorbent in a two-step solid-phase extraction method focussing upon complex biological matrices, specifically human urine and pig liver. This two-step solid-phase extraction protocol, in which a commercial Oasis HLB cartridge and a molecularly imprinted solid-phase extraction cartridge were combined, allowed enrofloxacin and ciprofloxacin to be determined by liquid chromatography coupled to a UV detector at levels below the maximum residue limits established by the European Union. The quantification and detection limits in tissue samples of enrofloxacin and ciprofloxacin were established at 50 μg kg−1 and 30 μg kg−1, respectively.

ORCID iDs

Cormack, Peter A.G. ORCID: https://orcid.org/0000-0002-3390-8176

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  Item type:	Article
  ID code:	35631
  Dates:	Date Event 15 March 2006 Published
  Keywords:	molecular imprinting , solid-phase extraction, fluorinated quinolones, urine samples, tissue samples, Chemistry, Biochemistry, Spectroscopy, Environmental Chemistry, Analytical Chemistry
  Subjects:	Science > Chemistry
  Department:	Faculty of Science > Pure and Applied Chemistry
  Depositing user:	Pure Administrator
  Date deposited:	09 Nov 2011 09:31
  Last modified:	20 Jan 2021 19:50
  URI:	https://strathprints.strath.ac.uk/id/eprint/35631