Synthetic approaches to parabens molecularly imprinted polymers and their applications to the solid-phase extraction of river water samples

Beltran, A. and Marce, R. M. and Cormack, P. A. G. and Borrull, F. (2010) Synthetic approaches to parabens molecularly imprinted polymers and their applications to the solid-phase extraction of river water samples. Analytica Chimica Acta, 677 (1). pp. 72-78. ISSN 0003-2670

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Abstract

Synthesis, characterization, and use of 2 distinct molecularly-imprinted polymers (MIP) prepd. using p-hydroxybenzoic acid (paraben) esters as templates are reported.: one MIP was synthesized by pptn. polymn. using a semi-covalent molecularly imprinting strategy with Me paraben as the template/target (MIP 1); the second MIP was prepd. in monolithic form through a conventional non-covalent mol. imprinting strategy, with Bu paraben as the template (MIP 2). One MIP was synthesized by pptn. polymn. using a semi-covalent molecularly imprinting strategy with Me paraben as the template/target (MIP 1); the second MIP was synthesized in monolithic form using a conventional, non-covalent mol. imprinting strategy with Bu paraben as the template (MIP 2). MIP 1 recognized Me paraben, showed cross-selectivity for other studied paraben analytes, and a higher affinity toward these compds. than a non-imprinted control polymer. Similarly, MIP 2 demonstrated a higher affinity toward paraben analytes than a non-imprinted control polymer. For anal. of environmental water, a solid phase extn. (SPE) protocol was developed using MIP 2 as sorbent; results were compared to SPE using a com. sorbent (Oasis HLB). With MIP 2 as sorbent and Bu paraben as target, when percolating 500 mL of river water spiked at 1 μg/L through the SPE cartridge, and using 1 mL of isopropanol as cleaning solvent, a higher Bu 4-hydroxybenzoate (Bu paraben) recovery and a cleaner chromatogram where achieved when using the MIP vs. the com. sorbent.