Evolution in the understanding of [Fe]-hydrogenase
Corr, Michael J and Murphy, John A (2011) Evolution in the understanding of [Fe]-hydrogenase. Chemical Society Reviews, 40 (5). pp. 2279-2292. ISSN 0306-0012 (https://doi.org/10.1039/c0cs00150c)
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Hydrogenases catalyse redox reactions with molecular hydrogen, either as substrate or product. The enzymes harness hydrogen as a reductant using metals that are abundant and economical, namely, nickel and iron, and should provide new pointers for the economic use of hydrogen in manmade devices. The most recently discovered and perhaps the most enigmatic of the hydrogenases is the [Fe]-hydrogenase, used by certain microorganisms in the pathway that reduces carbon dioxide to methane. Since its discovery some twenty years ago, [Fe]-hydrogenase has consistently provided structural and mechanistic surprises, often requiring complete re-evaluation of its mechanism of action. This tutorial review combines recent advances in X-ray crystallography and other analytical techniques, as well as in computational studies and in chemical synthesis to provide a platform for understanding this remarkable enzyme type.
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Item type: Article ID code: 34596 Dates: DateEvent2011Published1 March 2011Published OnlineSubjects: Science > Chemistry Department: Faculty of Science > Pure and Applied Chemistry Depositing user: Pure Administrator Date deposited: 20 Oct 2011 13:51 Last modified: 11 Nov 2024 09:54 Related URLs: URI: https://strathprints.strath.ac.uk/id/eprint/34596