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Open Access research that is better understanding work in the global economy...

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Better understanding the nature of work and labour within the globalised political economy is a focus of the 'Work, Labour & Globalisation Research Group'. This involves researching the effects of new forms of labour, its transnational character and the gendered aspects of contemporary migration. A Scottish perspective is provided by the Scottish Centre for Employment Research (SCER). But the research specialisms of the Department of Work, Employment & Organisation go beyond this to also include front-line service work, leadership, the implications of new technologies at work, regulation of employment relations and workplace innovation.

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Impaired Gluconeogenesis in a porcine model of paracetamol induced acute liver failure

Dabos, Konstantinos and Whalen, Henry and Newsome, Philip and Parkinson, John and Henderson, Neil and Sadler, Ian and Hayes, Peter and Plevris, John (2011) Impaired Gluconeogenesis in a porcine model of paracetamol induced acute liver failure. World Journal of Gastroenterology, 17 (11). pp. 1457-1461. ISSN 1007-9327

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Abstract

To investigate glucose homeostasis and in particular gluconeogenesis in a large animal model of acute liver failure (ALF). Six pigs with paracetamol induced ALF under general anaesthesia were studied over 25 h. Plasma samples were withdrawn every five hours from a central vein. Three animals were used as controls and were maintained under anaesthesia only. Using (1)H NMR spectroscopy we identified most gluconeogenic amino acids along with lactate and pyruvate in the animal plasma samples. No significant changes were observed in the concentrations of the amino acids studied in the animals maintained under anaesthesia only. If we look at the ALF animals, we observed a statistically significant rise of lactate (P < 0.003) and pyruvate (P < 0.018) at the end of the experiments. We also observed statistically significant rises in the concentrations of alanine (P < 0.002), glycine (P < 0.005), threonine (P < 0.048), tyrosine (P < 0.000), phenylalanine (P < 0.000) and isoleucine (P < 0.01). Valine levels decreased significantly (P < 0.05). Our pig model of ALF is characterized by an altered gluconeogenetic capacity, an impaired tricarboxylic acid (TCA) cycle and a glycolytic state.