Genetic and phenotypic effects of phonological short-term memory and grammatical morphology in specific language impairment

Tools

, ed. (2008) Genetic and phenotypic effects of phonological short-term memory and grammatical morphology in specific language impairment. Genes, Brain and Behavior, 7 (4). pp. 393-402. ISSN 1601-1848 (https://doi.org/10.1111/j.1601-183X.2007.00364.x)

Full text not available in this repository.Request a copy

Abstract

Deficits in phonological short-term memory and aspects of verb grammar morphology have been proposed as phenotypic markers of specific language impairment (SLI) with the suggestion that these traits are likely to be under different genetic influences. This investigation in 300 first-degree relatives of 93 probands with SLI examined familial aggregation and genetic linkage of two measures thought to index these two traits, non-word repetition and tense marking. In particular, the involvement of chromosomes 16q and 19q was examined as previous studies found these two regions to be related to SLI. Results showed a strong association between relatives’ and probands’ scores on non-word repetition. In contrast, no association was found for tense marking when examined as a continuous measure. However, significant familial aggregation was found when tense marking was treated as a binary measure with a cut-off point of −1.5 SD, suggestive of the possibility that qualitative distinctions in the trait may be familial while quantitative variability may be more a consequence of non-familial factors. Linkage analyses supported previous findings of the SLI Consortium of linkage to chromosome 16q for phonological short-term memory and to chromosome 19q for expressive language. In addition, we report new findings that relate to the past tense phenotype. For the continuous measure, linkage was found on both chromosomes, but evidence was stronger on chromosome 19. For the binary measure, linkage was observed on chromosome 19 but not on chromosome 16.

  • Item type:Article
    ID code:34140
    Dates:
    Date
    Event
    June 2008
    Published
    17 October 2007
    Published Online
    Notes:Authors of this paper are as follows: Falcaro, M. and Pickles, A and Newbury, DF and Addis, L and Banfield, E and Fisher, SE and Monaco, AP and Simkin, Z and Conti-Ramsden, G and Newbury, DF and Banfield, E and Addis, L and Cleak, JD and Cardon, LR and Merriden, MJ and Goodyer, IM and Simonoff, E and Bolton, PF and Slonims, V and Baird, G and Everitt, Andrea and Hennessy, E and Shaw, D and Helms, PJ and Kindley, AD and Clark, Ann and Watson, Jocelynne and O'Hare, Anne and Seckl, J and Cowie, H and Cohen, W and Nasir, J and Bishop, DVM
    Subjects:Medicine > Other systems of medicine
    Department:Faculty of Humanities and Social Sciences (HaSS) > Psychological Sciences and Health > Speech and Language Therapy
    Depositing user: Pure Administrator
    Date deposited:21 Oct 2011 11:14
    Last modified:11 Nov 2024 09:52
    URI:https://strathprints.strath.ac.uk/id/eprint/34140
CORE (COnnecting REpositories)