Direct electrochemiluminescence detection of oxidized DNA in ultrathin films containing [Os(bpy)(2)(PVP)(10)](2+)
Dennany, L and Forster, R J and White, B and Smyth, M and Rusling, J F (2004) Direct electrochemiluminescence detection of oxidized DNA in ultrathin films containing [Os(bpy)(2)(PVP)(10)](2+). Journal of the American Chemical Society, 126 (28). pp. 8835-8841. ISSN 0002-7863
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Direct electrochemiluminescence (ECL) involving oxidized DNA was demonstrated in ultrathin films of cationic polymer [Os(bpy)(2)(PVP)(10)](2+) [PVP = poly(vinyl pyridine)] assembled layer-by-layer with DNA or oligonucleotides. Electrochemically oxidized Os-II sites generated ECL from films containing oxo-guanines on DNA formed by chemical oxidation using Fenton reagent. Films combining DNA, [Ru(bpy)(2)(PVP)(10)](2+), and [Os(bpy)(2)(PVP)(10)](2+) had Os-II sites that produced ECL specific for oxidized DNA, and Ru-II sites gave ECL from reaction with oxo-adenines, chemically damaged DNA, and possibly from cleaved DNA strands.
Creators(s): |
Dennany, L ![]() | Item type: | Article |
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ID code: | 34098 |
Keywords: | mediated fenton reactions, hydrogen-peroxide, oxidative stress, oxygen radicals, electrochemical oxidation, strand breaks, in-vivo, iron, Chemistry, Biochemistry, Colloid and Surface Chemistry, Chemistry(all), Catalysis |
Subjects: | Science > Chemistry |
Department: | Faculty of Science > Pure and Applied Chemistry |
Depositing user: | Pure Administrator |
Date deposited: | 20 Oct 2011 12:46 |
Last modified: | 12 Feb 2021 03:58 |
URI: | https://strathprints.strath.ac.uk/id/eprint/34098 |
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