Preparation of pyrazolealkanamide substituted thiophenes as AMPA potentiators.
Gillen, Kevin James (2008) Preparation of pyrazolealkanamide substituted thiophenes as AMPA potentiators. WO2008003452A1.
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The title compds. I [wherein m = 1-4; R1 = CN or (un)substituted alkyl; R2 = acyl, (un)substituted alkyl, or alkoxy; R3 = H or (un)substituted Me; or R2 and R3 form a ring; R4 = CH2OH, CO2H, or (un)substituted CONH2; R5 and R6 = independently H or (cyclo)alkyl; or R5 and R6 form a ring], or pharmaceutically acceptable salts or solvates thereof were prepd. as AMPA potentiators. For example, II was prepd. in a multi-step synthesis. II gave an EC50 of 2.2 μM in pos. modulation of the AMPA (GluR1) receptor. The compds. ae useful in the treatment or prevention of psychiatric diseases, including schizophrenia, depression, and Alzheimer's disease (no data). [on SciFinder(R)]
Creators(s): |
Gillen, Kevin James, Jamieson, Craig ![]() | Item type: | Patent |
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ID code: | 33924 |
Notes: | M1 - Copyright (C) 2011 American Chemical Society (ACS). All Rights Reserved. CAPLUS AN 2008:42505(Patent) |
Subjects: | UNSPECIFIED |
Department: | Faculty of Science > Pure and Applied Chemistry |
Depositing user: | Pure Administrator |
Date deposited: | 20 Oct 2011 15:37 |
Last modified: | 04 Nov 2020 04:49 |
URI: | https://strathprints.strath.ac.uk/id/eprint/33924 |
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