Protease-activated receptor-2 (PAR-2) in the pathogenesis of osteoarthritis
Ferrell, William R. and Kelso, Elizabeth B. and Lockhart, John C. and Burns, Elizabeth and Plevin, Robin and McInnes, Iain B. (2011) Protease-activated receptor-2 (PAR-2) in the pathogenesis of osteoarthritis. Rheumatology, 50 (Supple). p. 90. ISSN 1462-0324
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Paper 125. Osteoarthritis (OA) is a global clinical challenge for which no effective disease-modifying agents currently exist. Proteinase activated receptor-2 (PAR-2) is a cell surface receptor activated by proteolytic cleavage, revealing a tethered ligand which binds to extracellular loop 2 resulting in intracellular signalling. We previously demonstrated a role for PAR-2 in adjuvant (1) and rheumatoid arthritis (2). As increasing evidence points to an inflammatory component in OA (3), in the present study we tested the hypothesis that PAR-2 may play a role in the pathogenesis of OA.
| Creators(s): |
Ferrell, William R., Kelso, Elizabeth B., Lockhart, John C., Burns, Elizabeth, Plevin, Robin  ORCID: https://orcid.org/0000-0002-7849-1220 and McInnes, Iain B.;
| Item type: | Article |
|---|---|
| ID code: | 31764 |
| Keywords: | osteoarthritis, protase, arthritis research, therapeutic treatment, Pharmacy and materia medica |
| Subjects: | Medicine > Pharmacy and materia medica |
| Department: | Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences |
| Depositing user: | Pure Administrator |
| Date deposited: | 22 Jun 2011 15:49 |
| Last modified: | 20 Jan 2021 19:25 |
| URI: | https://strathprints.strath.ac.uk/id/eprint/31764 |
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