Oxidative stress in fungal fermentation processes : the roles of alternative respiration
Li, Q. and Bai, Z. and O'Donnell, A. and Harvey, L. M. and Hoskisson, P. A. and McNeil, B. (2011) Oxidative stress in fungal fermentation processes : the roles of alternative respiration. Biotechnology Letters, 33 (3). pp. 457-467. ISSN 0141-5492 (https://doi.org/10.1007/s10529-010-0471-x)
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Filamentous fungi are arguably the most industrially important group of microorganisms. Production processes involving these simple eukaryotes are often highly aerobic in nature, which implies these cultures are routinely subject to oxidative stress. Despite this, little is known about how filamentous fungi cope with high levels of oxidative stress as experienced in fermenter systems. More surprisingly, much of our knowledge of oxidative stress responses in fungi comes from environmental or medical studies. Here, the current understanding of oxidative stress effects and cellular responses in filamentous fungi is critically discussed. In particular the role of alternative respiration is evaluated, and the contributions of the alternative oxidase and alternative dehydrogenases in defence against oxidative stress, and their profound influence on fungal metabolism is critically examined. Finally, the importance of further research which would underpin a less empirical approach to optimising fungal strains for the fermenter environment is emphasised.
ORCID iDs
Li, Q., Bai, Z., O'Donnell, A., Harvey, L. M., Hoskisson, P. A. ORCID: https://orcid.org/0000-0003-4332-1640 and McNeil, B.;-
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Item type: Article ID code: 31517 Dates: DateEventMarch 2011PublishedSubjects: Medicine > Pharmacy and materia medica Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences Depositing user: Pure Administrator Date deposited: 23 Jun 2011 13:41 Last modified: 26 Oct 2024 05:36 Related URLs: URI: https://strathprints.strath.ac.uk/id/eprint/31517