A novel therapeutic approach to cytokine modulation in articular inflammation using filarial nematode derived ES-62

McInnes, I.B. and Gracie, J.A. and Leung, B.P. and Harnett, M. and Liew, F.Y. and Harnett, W. (2003) A novel therapeutic approach to cytokine modulation in articular inflammation using filarial nematode derived ES-62. In: 23rd European Workshop for Rheumatology Research, 2003-03-27.

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    Abstract

    Meeting abstract on a novel therapeutic approach to cytokine modulation in articular inflammation. Discovering safe, novel immunomodulators that are effective in RA is currently a major therapeutic objective. Long-term immune system deviation is most striking in the host-parasite relationship, in which microbes may coexist with a human host. ES-62 exhibited powerful immunomodulation of CIA, preventing initiation of inflammatory arthritis. Crucially, ES-62 suppressed even established disease. These effects were due to inhibition of cytokine release, specifically TNF-α, and reversal of collagen specific Th1 responses associated with reduced expression of IFN-γ. The physiologic relevance of these observations was confirmed, as ES-62 down-regulated the release of proinflammatory cytokines (TNF-α and IL-6) from patient-derived samples.

    Author(s):McInnes, I.B., Gracie, J.A., Leung, B.P., Harnett, M., Liew, F.Y. and Harnett, W. ORCID logoORCID: https://orcid.org/0000-0001-9545-9401
    Item type:Conference or Workshop Item(Other)
    ID code:3133
    Notes:Also published in: Arthritis Research & Therapy (2003), 5 (Suppl.1), p52. (This is a variant record)
    Keywords:cytokine modulation, physiology, immunology, articular inflammation, Pharmacy and materia medica, Immunology
    Subjects:Medicine > Pharmacy and materia medica
    Science > Microbiology > Immunology
    Department:Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
    Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences > Centre for Biophotonics
    Depositing user: Strathprints Administrator
    Date deposited:17 Apr 2007
    Last modified:27 Nov 2019 05:30
    Related URLs:
    URI:https://strathprints.strath.ac.uk/id/eprint/3133
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