A novel therapeutic approach to cytokine modulation in articular inflammation using filarial nematode derived ES-62
McInnes, I.B. and Gracie, J.A. and Leung, B.P. and Harnett, M. and Liew, F.Y. and Harnett, W. (2003) A novel therapeutic approach to cytokine modulation in articular inflammation using filarial nematode derived ES-62. In: 23rd European Workshop for Rheumatology Research, 2003-03-27.
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Abstract
Meeting abstract on a novel therapeutic approach to cytokine modulation in articular inflammation. Discovering safe, novel immunomodulators that are effective in RA is currently a major therapeutic objective. Long-term immune system deviation is most striking in the host-parasite relationship, in which microbes may coexist with a human host. ES-62 exhibited powerful immunomodulation of CIA, preventing initiation of inflammatory arthritis. Crucially, ES-62 suppressed even established disease. These effects were due to inhibition of cytokine release, specifically TNF-α, and reversal of collagen specific Th1 responses associated with reduced expression of IFN-γ. The physiologic relevance of these observations was confirmed, as ES-62 down-regulated the release of proinflammatory cytokines (TNF-α and IL-6) from patient-derived samples.
Creators(s): |
McInnes, I.B., Gracie, J.A., Leung, B.P., Harnett, M., Liew, F.Y. and Harnett, W. ![]() | Item type: | Conference or Workshop Item(Other) |
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ID code: | 3133 |
Notes: | Also published in: Arthritis Research & Therapy (2003), 5 (Suppl.1), p52. (This is a variant record) |
Keywords: | cytokine modulation, physiology, immunology, articular inflammation, Pharmacy and materia medica, Immunology |
Subjects: | Medicine > Pharmacy and materia medica Science > Microbiology > Immunology |
Department: | Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences > Centre for Biophotonics |
Depositing user: | Strathprints Administrator |
Date deposited: | 17 Apr 2007 |
Last modified: | 23 Feb 2021 09:50 |
Related URLs: | |
URI: | https://strathprints.strath.ac.uk/id/eprint/3133 |
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