Cardosin A as a model aspartic proteinase for the study of organic solvent effects. An overview on catalytic and structural aspects

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Sarmento, A.C. and Oliveira, C. and Pires, E. and Halling, P.J. and Barros, M.T. (2003) Cardosin A as a model aspartic proteinase for the study of organic solvent effects. An overview on catalytic and structural aspects. Journal of Molecular Catalysis B: Enzymatic, 21 (1-2). pp. 19-23. ISSN 1381-1177 (http://dx.doi.org/10.1016/S1381-1177(02)00127-3)

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Abstract

Water has proven to be one of the several limitations for broadening the scope of applications of enzymes in biocatalysis, especially when the reactants involved are poorly water-soluble. The introduction of an organic solvent into the reaction system has numerous advantages. These include a direct action of the solvents on the reactants (improving their solubility) and on the reaction products (improving or diminishing their solubility), thereby increasing the productivity of the reaction system. Nevertheless, it has been documented that the introduction of an organic solvent into the reaction mixture may induce alterations on enzyme activity, enzyme stability and thermostability, and enzyme specificity thereby imprinting new properties to old enzymes.

ORCID iDs

Sarmento, A.C., Oliveira, C., Pires, E., Halling, P.J. ORCID logoORCID: https://orcid.org/0000-0001-5077-4088 and Barros, M.T.;
  • Item type:Article
    ID code:310
    Dates:
    Date
    Event
    2003
    Published
    Subjects:Science > Chemistry
    Department:Faculty of Science > Pure and Applied Chemistry
    Depositing user:Users 16 not found.
    Date deposited:13 Mar 2006
    Last modified:11 Nov 2024 08:24
    URI:https://strathprints.strath.ac.uk/id/eprint/310
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