Computer analysis of electrophysiological signals (biological techniques series)

Dempster, John (1993) Computer analysis of electrophysiological signals (biological techniques series). Biological techniques series . Academic Press. ISBN 0122089405

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Biological Techniques is a series of volumes aimed at introducing to a wide audience the latest advances in methodology. The pitfalls and problems of new techniques are given due consideration, as are those small but vital details not always explicit in the methods sections of journal papers. In recent years, most biological laboratories have been invaded by computers and a wealth of new DNA technology and this will be reflected in many of the titles appearing in the series. The books will be of value to advanced researchers and graduate students seeking to learn and apply new techniques, and will be useful to teachers of advanced undergraduate courses involving practical or project work. Over the past decade, the digital computer has come to play an increasingly important role in the analysis of electrophysiological signals, providing great improvements in measurement efficiency and precision. This book provides the first comprehensive introduction to the subject, covering a wide range of topics. A basic introduction to the principles of analog signal digitization is provided; including the choice of laboratory interface hardware, analog signal conditioning, and the presentation and analysis of digitized signal records. The subject is discussed in the context of the data acquisition hardware and software currently used in the electrophysiological laboratory. Particular attention is paid to the specialized techniques applied to various types of electrophysiological signal, with chapters on iterative curve fitting, the analysis of single channels, noise analysis, and voltage-activated whole cell currents. Detailed practical information on how to implement the techniques is provided, including some of the potential pitfalls. The source code for computer subroutines (for the IBM PC) implementing the recording of signals and numerous analysis functions are provided, forming a tool kit for the development of customized software. These routines include a spontaneous signal detector, signal averaging, and an iterative curve fitting algorithm.