Micromachined glass apertures for artificial lipid bilayer formation in a microfluidic system
Sandison, Mairi E. and Zagnoni, Michele and Abu-Hantash, Mustafa and Morgan, Hywel (2007) Micromachined glass apertures for artificial lipid bilayer formation in a microfluidic system. Journal of Micromechanics and Microengineering, 17 (7). S189-S196. ISSN 0960-1317 (https://doi.org/doi:10.1088/0960-1317/17/7/S17)
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The use of spark assisted chemical engraving (SACE) to produce glass apertures that are suitable for the formation of artificial bilayer lipid membranes is described. Prior to use, the glass apertures were rendered hydrophobic by a silanization process and were then incorporated into a simple microfluidic device. Successful bilayer lipid membrane (BLM) formation and the subsequent acquisition of single-channel recordings are demonstrated. Due to the simplicity and rapidity of the SACE process, these glass apertures could be easily integrated into an all-glass microfluidic system for BLM formation.
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Item type: Article ID code: 29056 Dates: DateEvent2 July 2007PublishedSubjects: Technology > Electrical engineering. Electronics Nuclear engineering Department: Faculty of Engineering > Electronic and Electrical Engineering
Faculty of Engineering > Biomedical EngineeringDepositing user: Pure Administrator Date deposited: 25 Mar 2011 11:23 Last modified: 08 Apr 2024 18:49 URI: https://strathprints.strath.ac.uk/id/eprint/29056