Micromachined glass apertures for artificial lipid bilayer formation in a microfluidic system

Sandison, Mairi E. and Zagnoni, Michele and Abu-Hantash, Mustafa and Morgan, Hywel (2007) Micromachined glass apertures for artificial lipid bilayer formation in a microfluidic system. Journal of Micromechanics and Microengineering, 17 (7). S189-S196. ISSN 0960-1317

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Abstract

The use of spark assisted chemical engraving (SACE) to produce glass apertures that are suitable for the formation of artificial bilayer lipid membranes is described. Prior to use, the glass apertures were rendered hydrophobic by a silanization process and were then incorporated into a simple microfluidic device. Successful bilayer lipid membrane (BLM) formation and the subsequent acquisition of single-channel recordings are demonstrated. Due to the simplicity and rapidity of the SACE process, these glass apertures could be easily integrated into an all-glass microfluidic system for BLM formation.

Creators(s): Sandison, Mairi E. ORCID logoORCID: https://orcid.org/0000-0003-1021-1461, Zagnoni, Michele ORCID logoORCID: https://orcid.org/0000-0003-3198-9491, Abu-Hantash, Mustafa and Morgan, Hywel;
Item type:Article
ID code:29056
Keywords:micromachining, glass apertures, artificial lipid bilayer, biological physics, Electrical engineering. Electronics Nuclear engineering, Mechanics of Materials, Mechanical Engineering, Electronic, Optical and Magnetic Materials, Electrical and Electronic Engineering
Subjects:Technology > Electrical engineering. Electronics Nuclear engineering
Department:Faculty of Engineering > Electronic and Electrical Engineering
Faculty of Engineering > Biomedical Engineering
Depositing user: Pure Administrator
Date deposited:25 Mar 2011 11:23
Last modified:15 Jan 2021 04:17
URI:https://strathprints.strath.ac.uk/id/eprint/29056
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