Biocatalytic induction of supramolecular order
Hirst, Andrew R. and Roy, Sangita and Arora, Meenakshi and Das, Apurba and Hodson, Nigel and Murray, Paul and Marshall, Stephen and Javid, Nadeem and Sefcik, Jan and Boekhoven, Job and van Esch, Jan H. and Santabarbara, Stefano and Hunt, Neil T. and Ulijn, Rein V. (2010) Biocatalytic induction of supramolecular order. Nature Chemistry, 2 (12). 1089–1094. ISSN 1755-4330 (https://doi.org/10.1038/nchem.861)
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Supramolecular gels, which demonstrate tunable functionalities, have attracted much interest in a range of areas, including healthcare, environmental protection and energy-related technologies. Preparing these materials in a reliable manner is challenging, with an increased level of kinetic defects observed at higher self-assembly rates. Here, by combining biocatalysis and molecular self-assembly, we have shown the ability to more quickly access higher-ordered structures. By simply increasing enzyme concentration, supramolecular order expressed at molecular, nano- and micro-levels is dramatically enhanced, and, importantly, the gelator concentrations remain identical. Amphiphile molecules were prepared by attaching an aromatic moiety to a dipeptide backbone capped with a methyl ester. Their self-assembly was induced by an enzyme that hydrolysed the ester. Different enzyme concentrations altered the catalytic activity and size of the enzyme clusters, affecting their mobility. This allowed structurally diverse materials that represent local minima in the free energy landscape to be accessed based on a single gelator structure.
ORCID iDs
Hirst, Andrew R., Roy, Sangita, Arora, Meenakshi, Das, Apurba, Hodson, Nigel, Murray, Paul ORCID: https://orcid.org/0000-0002-6980-9276, Marshall, Stephen ORCID: https://orcid.org/0000-0001-7079-5628, Javid, Nadeem, Sefcik, Jan ORCID: https://orcid.org/0000-0002-7181-5122, Boekhoven, Job, van Esch, Jan H., Santabarbara, Stefano, Hunt, Neil T. ORCID: https://orcid.org/0000-0001-7400-5152 and Ulijn, Rein V. ORCID: https://orcid.org/0000-0001-7974-3779;-
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Item type: Article ID code: 27078 Dates: DateEventDecember 2010Published10 October 2010Published OnlineSubjects: Technology > Chemical technology
Science > ChemistryDepartment: Faculty of Science > Pure and Applied Chemistry
Faculty of Science > Physics
Faculty of Engineering > Electronic and Electrical Engineering
Faculty of Engineering > Chemical and Process EngineeringDepositing user: Miss Fiona Buggy Date deposited: 15 Nov 2010 16:56 Last modified: 12 Dec 2024 02:32 Related URLs: URI: https://strathprints.strath.ac.uk/id/eprint/27078