Early detection of amyloid aggregation using intrinsic fluorescence

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Rolinski, O.J. and Amaro, M. and Birch, D.J.S. (2010) Early detection of amyloid aggregation using intrinsic fluorescence. Biosensors and Bioelectronics, 25 (10). pp. 2249-2252. ISSN 0956-5663 (https://doi.org/10.1016/j.bios.2010.03.005)

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Abstract

Beta-amyloid (Au) aggregation, believed to be responsible for Alzheimer's disease, is monitored using its intrinsic fluorescence decay. Alterations in the fluorescence decay of tyrosine correlate with the A beta aggregation at a much earlier stage than the traditionally used fluorescence intensity of Thioflavin T (ThT). Potentially the finding may underpin progress towards an earlier diagnosis of the onset of Alzheimer's disease and an improved approach to developing intervention therapies.

ORCID iDs

Rolinski, O.J. ORCID logoORCID: https://orcid.org/0000-0002-7838-779X, Amaro, M. and Birch, D.J.S. ORCID logoORCID: https://orcid.org/0000-0001-6400-1270;
  • Item type:Article
    ID code:26575
    Dates:
    Date
    Event
    15 June 2010
    Published
    Subjects:Science > Physics
    Department:Faculty of Science > Physics
    Depositing user:Users 1261 not found.
    Date deposited:10 Aug 2010 13:14
    Last modified:11 Nov 2024 09:37
    URI:https://strathprints.strath.ac.uk/id/eprint/26575
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