Construction of DNA architectures with RNA Hairpins

Mayer, G. and Ackermann, Damian and Kuhn, Nicole and Famulok, Michael (2008) Construction of DNA architectures with RNA Hairpins. Agewandte Chemie-International Edition, 47 (5). pp. 971-973. ISSN 1433-7851

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Abstract

Kissing complexes formed on the basis of highly specific noncanonical interactions of RNA hairpins can be harnessed for the controlled assembly of DNA nanoobjects. Two DNA minicircles, each equipped with a different RNA hairpin motif (see picture), mediate a tight and specific binding of the two circular DNA nanoobjects. These interactions may offer the possibility to construct DNA nanoobjects with increased complexity.