Construction of DNA architectures with RNA Hairpins

Mayer, G. and Ackermann, Damian and Kuhn, Nicole and Famulok, Michael (2008) Construction of DNA architectures with RNA Hairpins. Agewandte Chemie-International Edition, 47 (5). pp. 971-973. ISSN 1433-7851

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Kissing complexes formed on the basis of highly specific noncanonical interactions of RNA hairpins can be harnessed for the controlled assembly of DNA nanoobjects. Two DNA minicircles, each equipped with a different RNA hairpin motif (see picture), mediate a tight and specific binding of the two circular DNA nanoobjects. These interactions may offer the possibility to construct DNA nanoobjects with increased complexity.