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Driving innovations in manufacturing: Open Access research from DMEM

Strathprints makes available Open Access scholarly outputs by Strathclyde's Department of Design, Manufacture & Engineering Management (DMEM).

Centred on the vision of 'Delivering Total Engineering', DMEM is a centre for excellence in the processes, systems and technologies needed to support and enable engineering from concept to remanufacture. From user-centred design to sustainable design, from manufacturing operations to remanufacturing, from advanced materials research to systems engineering.

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Putting pressure on elusive polymorphs and solvates

Oswald, I.D.H. and Chataigner, I. and Elphick, S. and Fabbiani, F.P.A. and Lennie, Alistair R. and Maddaluno, J. and Marshall, William G. and Prior, T.J. and Pulham, Colin R. and Smith, Ronald I. (2009) Putting pressure on elusive polymorphs and solvates. CrystEngComm, 11 (2). pp. 359-366. ISSN 1466-8033

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Abstract

The reproducible crystallisation of elusive polymorphs and solvates of molecular compounds at high pressure has been demonstrated through studies on maleic acid, malonamide, and paracetamol. These high-pressure methods can be scaled-up to produce bulk quantities of metastable forms that can be recovered to ambient pressure for subsequent seeding experiments. This has been demonstrated for paracetamol form II and paracetamol monohydrate. The studies also show that the particular solid form can be tuned by both pressure and concentration.