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Strathprints

A novel therapeutic approach to cytokine modulation in articular inflammation using filarial nematode derived ES-62

McInnes, I.B. and Gracie, J.A. and Leung, B.P. and Harnett, M.M. and Liew, F.Y. and Harnett, W. (2003) A novel therapeutic approach to cytokine modulation in articular inflammation using filarial nematode derived ES-62. Arthritis Research and Therapy, 5 (Suppl ). p. 52. ISSN 1478-6354

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Abstract

Discovering safe, novel immunomodulators that are effective in RA is currently a major therapeutic objective. Long-term immune system deviation is most striking in the host-parasite relationship, in which microbes may coexist with a human host. ES-62 exhibited powerful immunomodulation of CIA, preventing initiation of inflammatory arthritis. Crucially, ES-62 suppressed even established disease. These effects were due to inhibition of cytokine release, specifically TNF-α, and reversal of collagen specific Th1 responses associated with reduced expression of IFN-γ. The physiologic relevance of these observations was confirmed, as ES-62 down-regulated the release of proinflammatory cytokines (TNF-α and IL-6) from patient-derived samples.

Author(s):McInnes, I.B., Gracie, J.A., Leung, B.P., Harnett, M.M., Liew, F.Y. and Harnett, W.
Item type:Article
ID code:22587
Notes:Meeting abstract presented at: 23rd European Workshop for Rheumatology Research, Marseille, France. 27 February – 2 March 2003. Variant of 133977
Keywords:cytokine modulation, physiology, immunology, articular inflammation, Pharmacy and materia medica, Immunology, Immunology, Rheumatology, Immunology and Allergy
Subjects:Medicine > Pharmacy and materia medica
Science > Microbiology > Immunology
Department:Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences > Centre for Biophotonics
Depositing user: Strathprints Administrator
Date deposited:23 Sep 2010 11:42
Last modified:03 Jan 2019 12:34
URI:https://strathprints.strath.ac.uk/id/eprint/22587
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