Inhibition of system L (LAT1/CD98hc) reduces the growth of cultured human breast cancer cells

Shennan, D.B. and Thomson, Jean (2008) Inhibition of system L (LAT1/CD98hc) reduces the growth of cultured human breast cancer cells. Oncology Reports, 20 (4). pp. 885-889. ISSN 1021-335X (http://dx.doi.org/10.3892/or_00000087)

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Abstract

It has been suggested that system L (LAT1/CD98hc) is up-regulated in cancer cells, including breast tumour cells, and is therefore a promising molecular target to inhibit or limit tumour cell growth. In view of this, we have examined the effect of BCH and other inhibitors of system L on the growth of MCF-7, ZR-75-1 and MDA-MB-231 cells. Treating cells with BCH markedly inhibited the metabolism of WST-1 in a dose-dependent fashion. Similarly, melphalan and D-leucine inhibited the growth of cultured breast cancer cells whereas MeAIB, an inhibitor of system A, was without effect. The effects of BCH and melphalan on cell growth were non-additive suggesting that both compounds were acting at a single locus. The results indicate that system L is required to maintain MCF-7, ZR-75-1 and MDA-MB-231 cell growth and support the notion that LAT1/CD98hc may be a suitable target to inhibit breast cancer progression.

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