Nanomedicine and its potential in diabetes research and practice

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Pickup, J.C. and Zhi, Z.L. and Khan, F. and Saxl, T. and Birch, D.J.S. (2008) Nanomedicine and its potential in diabetes research and practice. Diabetes-Metabolism Research and Reviews, 24 (8). pp. 604-610. ISSN 1520-7552 (http://dx.doi.org/10.1002/dmrr.893)

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Abstract

Nanomedicine involves measurement and therapy at the level of 1-100 nm. Although the science is still in its infancy, it has major potential applications in diabetes. These include solving needs such as non-invasive glucose monitoring using implanted nanosensors, with key techniques being fluorescence resonance energy transfer (FRET) and fluorescence lifetime sensing, as well as new nano-encapsulation technologies for sensors such as layer-by-layer (LBL) films. The latter might also achieve better insulin delivery in diabetes by both improved islet encapsulation and oral insulin formulations. An artificial nanopancreas could be an alternative closed-loop insulin delivery system. Other applications of nanomedicine include targeted molecular imaging in vivo (e.g. tissue complications) using quantum dots (QDs) or gold nanoparticles, and single-molecule detection for the study of molecular diversity in diabetes pathology

ORCID iDs

Pickup, J.C., Zhi, Z.L., Khan, F., Saxl, T. and Birch, D.J.S. ORCID logoORCID: https://orcid.org/0000-0001-6400-1270;
CORE (COnnecting REpositories)