Analysis of E3 ubiquitin-protein ligases in antigen-specific CD4(+) T cells during tolerance and priming

Bicheiro, L. and Morton, A.M. and Garside, P. and Mowat, A.M. and Harnett, M.M. (2008) Analysis of E3 ubiquitin-protein ligases in antigen-specific CD4(+) T cells during tolerance and priming. Immunology, 125 (s1). p. 128. ISSN 0019-2805 (http://dx.doi.org/10.1111/j.1365-2567.2008.02974.x)

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Abstract

Peripheral tolerance plays an important role in preventing T lymphocyte responses to self or harmless antigens. One of the mechanisms that contributes to this form of tolerance is anergy, which is characterized by a lack of proliferation and IL-2 production by T cells in response to antigenic challenge. The acquisition of the anergic phenotype is an active process, with negative regulators of T cell signaling being induced. Among these are the E3 ubiquitin-protein ligases which recognize target proteins for ubiquitination and catalyze the transfer of ubiquitin to them, directing them to the proteasome or to the endosome-lysosomal pathway, and hence down-regulating their activity.

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