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Open Access research with a European policy impact...

The Strathprints institutional repository is a digital archive of University of Strathclyde's Open Access research outputs. Strathprints provides access to thousands of Open Access research papers by Strathclyde researchers, including by researchers from the European Policies Research Centre (EPRC).

EPRC is a leading institute in Europe for comparative research on public policy, with a particular focus on regional development policies. Spanning 30 European countries, EPRC research programmes have a strong emphasis on applied research and knowledge exchange, including the provision of policy advice to EU institutions and national and sub-national government authorities throughout Europe.

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Intra-articular injection composed of steroid, iohexol and local anaesthetic - is it stable?

Shah, K. and Watson, D.G. and Campbell, C. and Meek, R.M.D. (2009) Intra-articular injection composed of steroid, iohexol and local anaesthetic - is it stable? British Journal of Radiology, 82 (974). pp. 109-111. ISSN 0007-1285

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Abstract

The aim of this study is to determine the chemical stability of a suspension of steroid, radiographic contrast material and local anaesthetic. Image-guided steroid injection using a contrast material is widely used for several musculoskeletal conditions. Manufacturers of these agents do not advise mixture in a single syringe, as the chemical stability is unknown. They suggest that, if required, these agents should be injected separately. However, the agents will be mixed together when injected into a contained space within the body. it would seem unethical to continue this in clinical practice until the stability of such a mixture is established. High-performance liquid chromatographic (HPLC) analysis was used to assess the stability of combinations of steroids (triamcinolone and methylprednisolone) and Omnipaque (TM) (iohexol). Further analysis was also performed to test the stability of adding local anaesthetics (lidocaine and bupivacaine) to these mixtures. The results demonstrated that all combinations were stable when mixed together. in conclusion, these results support the continued safe use of these products in combination in clinical practice.