Picture of DNA strand

Pioneering chemical biology & medicinal chemistry through Open Access research...

Strathprints makes available scholarly Open Access content by researchers in the Department of Pure & Applied Chemistry, based within the Faculty of Science.

Research here spans a wide range of topics from analytical chemistry to materials science, and from biological chemistry to theoretical chemistry. The specific work in chemical biology and medicinal chemistry, as an example, encompasses pioneering techniques in synthesis, bioinformatics, nucleic acid chemistry, amino acid chemistry, heterocyclic chemistry, biophysical chemistry and NMR spectroscopy.

Explore the Open Access research of the Department of Pure & Applied Chemistry. Or explore all of Strathclyde's Open Access research...

Bioactive constituents from bergia suffruticosa

Elegami, A.A. and Gray, A.I. and Waigh, R.D. and Khalid, H.E. (2009) Bioactive constituents from bergia suffruticosa. Planta Medica, 75 (9). p. 963. ISSN 0032-0943

Full text not available in this repository. Request a copy from the Strathclyde author

Abstract

In vitro antibacterial investigation of the various extracts of Bergia suffruticosa leaf belonging to the family Elatinaceae: a plant used in Sudanese folk medicine to treat skin wounds [1] was evaluated against 72 strains of standard and clinical isolates of Gram positive and Gram negative bacteria. Six known compounds were isolated from methanolic extract, which was the most active fraction. The isolated compounds were Gallic acid methyl ester; Daucosterol; 1,2,3,6-Tetra-O-galloyl -β-glucose; 1,2,3,4,6-Penta-O-galloyl-β-glucose; Kaemferol-3-O-rhamnoside and Quercetin-3-O-rhamnoside. Their identification were based on their spectroscopic data (UV, IR, 1H & 13CNMR and MS). Gallic acid methyl ester was found to have MIC 25µg/ml against Staphylococcus aureus and Escherichia coli, whereas 1,2,3,6-Tetra-O-galloyl -β-glucose and 1,2,3,4,6-Penta-O-galloyl-β-glucose were found to be 50µg/ml against S. aureus and 100µg/ml against E. coli, the results suggested that the antibacterial effect of these two compounds is due to the presence of galloyl group. The MIC of other three compounds displayed no antibacterial activity against both organisms at 200µg/ml. Ampicillin and Gentamicin were used as reference antibacterial activity. In an early study, conducted the antibacterial activity of B. suffruticosa whole plant reported that, its methanolic extract showed significant inhibition of the four tested micro-organisms [2]. There is no phytochemical report encountered on the plant species undertaken in this study. This result justifies the traditional therapeutic use of the plant.