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Preliminary results on safety and activity of a randomized, double-blind, 2 x 2 trial of low-dose tamoxifen and fenretinide for breast cancer prevention in premenopausal women

Guerrieri-Gonzaga, A. and Robertson, C. and Bonanni, B. and Serrano, D. and Cazzaniga, M. and Mora, S. and Gulisano, M. and Johansson, H. (2006) Preliminary results on safety and activity of a randomized, double-blind, 2 x 2 trial of low-dose tamoxifen and fenretinide for breast cancer prevention in premenopausal women. Journal of Clinical Oncology, 24 (1). pp. 129-135. ISSN 0732-183X

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Abstract

To determine whether low-dose tamoxifen and fenretinide have a synergistic effect on surrogate biomarkers, including circulating insulin-like growth factor I (IGF-I) and mammographic density, in premenopausal women at risk for breast cancer and to study drug safety.