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Open Access research with a European policy impact...

The Strathprints institutional repository is a digital archive of University of Strathclyde's Open Access research outputs. Strathprints provides access to thousands of Open Access research papers by Strathclyde researchers, including by researchers from the European Policies Research Centre (EPRC).

EPRC is a leading institute in Europe for comparative research on public policy, with a particular focus on regional development policies. Spanning 30 European countries, EPRC research programmes have a strong emphasis on applied research and knowledge exchange, including the provision of policy advice to EU institutions and national and sub-national government authorities throughout Europe.

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Laryngeal carcinoma: treatment interruption and outcome

Robertson, A.G. and Robertson, C. and Wheldon, T.E. and Boyle, P. and Symonds, R.P. (1995) Laryngeal carcinoma: treatment interruption and outcome. European Journal of Cancer, 31 (Supple). S85-S85. ISSN 0959-8049

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Abstract

Two patient groups have been identified from a data base of 965 patients with carcinoma of the larynx. One group of 393 patients had squamous cell carcinoma of the larynx arising in the glottis--no nodal involvement; the other group of 163 patients had tumours arising in the supraglottic region. The second group was a more heterogenous group some patients had nodal involvement at the time of presentation. All patients were treated on a linear accelerator. Patients were treated using a variety of dose-fraction-time schedules. Mathematical modelling using linear quadratic equation was carried out. This shows that a break in treatment if a week reduces the local tumour rate for glottic tumours by 12% or about 25 per day. Local tumour control rates increased as the effective dose was increased. The data for tumours arising in the supraglottic region is not so convincing though it does show that prolongation of treatment time reduces local tumour control rates. The effects of longer times can be nullified by increasing the effective dose. The supraglottic subject, however, is very heterogenous, and the groups within the subset are small.