Picture of UK Houses of Parliament

Leading national thinking on politics, government & public policy through Open Access research

Strathprints makes available scholarly Open Access content by researchers in the School of Government & Public Policy, based within the Faculty of Humanities & Social Sciences.

Research here is 1st in Scotland for research intensity and spans a wide range of domains. The Department of Politics demonstrates expertise in understanding parties, elections and public opinion, with additional emphases on political economy, institutions and international relations. This international angle is reflected in the European Policies Research Centre (EPRC) which conducts comparative research on public policy. Meanwhile, the Centre for Energy Policy provides independent expertise on energy, working across multidisciplinary groups to shape policy for a low carbon economy.

Explore the Open Access research of the School of Government & Public Policy. Or explore all of Strathclyde's Open Access research...

Response to drug treatment in newly diagnosed epilepsy: a pilot study of 1H NMR- and MS-based metabonomic analysis

Sills, G. and Alzweiri, M. and Leach, J. and Brodie, M. and Robertson, C. and Watson, D.G. and Parkinson, J.A. (2010) Response to drug treatment in newly diagnosed epilepsy: a pilot study of 1H NMR- and MS-based metabonomic analysis. Epilepsy Research, 88 (2-3). pp. 189-195. ISSN 0920-1211

Full text not available in this repository.Request a copy from the Strathclyde author

Abstract

Understanding the biological basis of drug resistance and developing techniques which facilitate prediction of outcome have the potential to revolutionise the pharmacotherapy of epilepsy.We have performed a pilot study of metabonomic analysis using nuclear magnetic resonance(NMR) spectroscopy and mass spectrometry (MS) in an effort to identify metabolic biomarkers of response to antiepileptic drug treatment. Pretreatment serum samples were obtained from 125 patients with newly diagnosed epilepsy who were taking part in a randomized monotherapy trial. Outcome (responder, nonresponder) was assessed at 6 weeks, 6 months, and 12 months after starting treatment. Serum samples were subject to investigation by both NMR and MS and the resulting data interrogated by principal component analysis. There was no clear distinction in the metabolic profile, acquired by either NMR or MS, of responders and nonresponders to AED treatment at any of the three clinical end points investigated, suggesting that pretreatment serum samples do not contain any prominent biomarkers of responsiveness to initial treatment in new-onset epilepsy. Metabonomic analysis is undoubtedly applicable to the search for biological predictors of response to drug treatment in epilepsy, but future studies should employ larger patient cohorts, more discriminatory analyses, and a less equivocal clinical phenotype.